New Theophylline Derivatives

de Ali Mahmoud Elgaher, Walid
État : Neuf
77,79 €
TVA incluse - Livraison GRATUITE
Ali Mahmoud Elgaher, Walid New Theophylline Derivatives
Ali Mahmoud Elgaher, Walid - New Theophylline Derivatives

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77,79 € dont de TVA
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Livraison : entre jeudi 26 mai 2022 et lundi 30 mai 2022
Vente et expédition: Dodax

La description

Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years. Recently, it was found that bacterial infection plays a role in asthma pathogenesis. Accordingly, the present work involves the synthesis of different series of 8-substituted theophylline derivatives as novel antiasthmatic candidates with potential antibacterial activity. A pharmacophore model was constructed to get useful insight into the essential structural features of bronchodilator activity. Forty-six of the target compounds were investigated for in vivo antiasthmatic activity using aminophylline as a reference standard. Antibacterial activity of all the target compounds was investigated in vitro against both Gram-positive and Gram-negative bacterial strains using ampicillin as a reference standard. Acute toxicity study was also performed. It is noteworthy to mention that compounds 6c, 8i1, and 14c combined both promising antiasthmatic and antibacterial activities. These compounds may act as a corner stone for further investigations by medicinal chemists in development of new theophylline derivatives for the treatment of bronchial asthma.


Ali Mahmoud Elgaher, Walid

Détails du produit

Walid A. M. Elgaher: BSc. in Pharmaceutical Sciences (Excellent with honor degree). MSc. in Pharmaceutical Organic Chemistry. Assistant lecturer at Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Egypt. Awarded a GERLS scholarship by the German Academic Exchange Service (DAAD) for doctorate studies in Germany
Nombre de pages:
Type de média:
LAP Lambert Academic Publishing

Données de base

Type d'produit:
Livre de poche
Date de publication:
5 juillet 2011
Dimensions du colis:
0.22 x 0.15 x 0.012 m; 0.349 kg
77,79 €
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