Brittle Fracture Index as a Tool for Tablet Binder Selection

de Yedavalli, Radha Krishna
État : Neuf
63,89 €
TVA incluse - Livraison GRATUITE
Yedavalli, Radha Krishna Brittle Fracture Index as a Tool for Tablet Binder Selection
Yedavalli, Radha Krishna - Brittle Fracture Index as a Tool for Tablet Binder Selection

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La description

The effect of binder type and concentration on six high dose drugs was evaluated. The drugs which are used in this experiment are already in market and are available at a very high dose of 500mg and above. Three binders were used in the work at two different user levels. The binders are chosen of different chemistries so in order to predict a optimized formulation for each of the drug. The brittle fracture index of the formulation is calculated by compressing tablets with hole, the hole is an inbuilt defect which will help in propagation of crack into the tablet and enable capping and lamination. The tensile strengths of tablet with hole and without hole are used in calculating BFI. The so calculated BFI is correlated to the dissolution profile of the formulations and the most stable formulation can be formed. Here all the formulations showed excellent results minimum BFI values except Metformin HCl and Paracetamol giving high BFI values indicating susceptibility to Capp or laminate where as Efavirenz and Ciprofloxacin with low BFI values and less susceptible to Capp or laminate. Whereas Metformin has no dissolution failure but Efavirenz has dissolution issues.

Contributeurs

Écrivain:
Yedavalli, Radha Krishna
L., Sai Koundinya
Salomy, Sanjana

Détails du produit

Biographie:
Radha Krishna Y, M.Pharm. Studied Masters in Pharmacy at Biju Patnayak University of Technology. Research Scientist at Bhavy's International Pharmaceutical Sciences Private Limited, Hyderabad.
Langues:
Anglais
Nombre de pages:
164
Type de média:
Souple
Éditeur:
LAP Lambert Academic Publishing

Données de base

Type d'produit:
Livre de poche
Date de publication:
17 mars 2014
Dimensions du colis:
0.224 x 0.152 x 0.014 m; 0.28 kg
GTIN:
09783659271601
DUIN:
EVDLJ8PBIMH
63,89 €
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