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Novel iron chelators for iron overload disease and cancer treatment

Development of novel iron chelators for the treatment of iron overload disease and cancer
de Danuta Kalinowski - Vendu par Dodax EU
État : Neuf
76,32 €
TVA incluse - Livraison GRATUITE
Danuta Kalinowski Novel iron chelators for iron overload disease and cancer treatment
Danuta Kalinowski - Novel iron chelators for iron overload disease and cancer treatment

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76,32 € dont de TVA
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Livraison : entre 2021-01-26 et 2021-01-28
Vente et expédition: Dodax EU

Description

Iron (Fe) chelation therapy involves the use of drugs that avidly bind Fe from biological systems. Iron chelators were developed for the treatment of Fe overload diseases, B-thalassemia and Friedreich's ataxia. However, the increased requirement for Fe in rapidly proliferating cancer cells, compared to normal cells, makes Fe a target for cancer chemotherapy. Iron chelators remove Fe from Fe-containing proteins, including ribonucleotide reductase, a key enzyme involved in the rate-limiting step of DNA synthesis and inhibit proliferation. Chelators with potent antiproliferative activity also demonstrate the ability to form Fe complexes that redox cycle. This leads to the generation of reactive oxygen species which induce DNA oxidation and mitochondrial damage. The investigations described in this book detail several structural features involved in targeting ligands for either the treatment of Fe overload disease or cancer chemotherapy. These findings emphasise the importance of donor atom identity and inductive effects on the redox cycling and antiproliferative activity of aroylhydrazone, thiohydrazone and thiosemicarbazone Fe chelators.

Contributeurs

Auteur Danuta Kalinowski

Auteur Des R. Richardson

Détails sur le produit

DUIN 1KM74BOI73G

GTIN 9783838300283

Date de publication 16.10.2018

Langues Anglais

Nombre de pages 288

Type de produit Livre de Poche

Dimension 220 x 150  mm

76,32 €
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